Cancers, Skin, General

Important
It is possible that the main title of the report Cancers, Skin, General is not the name you expected.

Disorder Subdivisions

• Melanoma, Malignant
• Squamous Cell Carcinomas
• Acral Lentiginious Melanoma
• Juvenile Melanoma
• Kaposi's Sarcoma
• Malignant Lentico Melanoma
• Skin Cancer, Non-Melanoma
• Basal Cell Carcinoma

General Discussion

There are many different types of Skin Cancer. Combined together all types of Skin Cancer represent the most prevalent type of cancer. Most skin cancers are characterized by changes in the color or texture of the skin, but some types begin under the skin where they can spread to other parts of the body. Malignant melanoma is the most dangerous of this type of skin cancer.

Resources

American Childhood Cancer Organization
10920 Connecticut Ave
Suite A
Kensington, MD 20895
Tel: (301)962-3520
Fax: (301)962-3521
Tel: (800)366-2223
Email: staff@acco.org
Internet: http://www.candlelighters.org

Skin Cancer Foundation
245 Fifth Avenue
Suite 2402
New York, NY 10016
Tel: (212)725-5176
Fax: (212)725-5751
Tel: (800)754-6490
Email: info@skincancer.org
Internet: http://www.skincancer.org

American Cancer Society, Inc.
1599 Clifton Road NE
Atlanta, GA 30329
USA
Tel: (404)320-3333
Tel: (800)227-2345
TDD: (866)228-4327
Internet: http://www.cancer.org

National Cancer Institute
6116 Executive Blvd
MSC 8322
Room 3036A
Bethesda, MD 20892-8322
USA
Tel: (301)435-3848
Tel: (800)422-6237
TDD: (800)332-8615
Email: cancergovstaff@mail.nih.gov
Internet: http://www.cancer.gov

OncoLink: The University of Pennsylvania Cancer Center Resource
3400 Spruce Street
2 Donner
Philadelphia, PA 19104-4283
USA
Tel: (215)349-8895
Fax: (215)349-5445
Email: hampshire@uphs.upenn.edu
Internet: http://www.oncolink.upenn.edu

Cancer Research UK
61 Lincoln's Inn Fields
London, Intl WC2A 3PX
United Kingdom
Tel: 020 7121 6699
Fax: 020 7121 6700
Email: cancerhelpuk@cancer.org.uk
Internet: http://www.cancerhelp.org.uk

Rare Cancer Alliance
1649 North Pacana Way
Green Valley, AZ 85614
USA
Tel: (520)625-5495
Fax: (615)526-4921
Internet: http://www.rare-cancer.org

MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
USA
Tel: (920)336-5333
Fax: (920)339-0995
Tel: (877)336-5333
Email: mums@netnet.net
Internet: http://www.netnet.net/mums/

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Internet: http://rarediseases.info.nih.gov/GARD/

Friends of Cancer Research
1800 M Street NW
Suite 1050 South
Washington, DC 22202
Tel: (202)944-6700
Email: info@focr.org
Internet: http://www.focr.org

Cancer.Net
American Society of Clinical Oncology
2318 Mill Road
Suite 800
Alexandria, VA 22314
Tel: (571)483-1780
Fax: (571)366-9537
Tel: (888)651-3038
Email: contactus@cancer.net
Internet: http://www.cancer.net/patient

Cancer Support Community
1050 17th St NW
Washington, DC 20036
Tel: (202)659-9709
Fax: (202)974-7999
Tel: (888)793-9355
Internet: http://www.cancersupportcommunity.org/

Lance Armstrong Foundation
2201 E. Sixth Street
Austin, TX 78702
Tel: (512)236-8820
Fax: (512)236-8482
Tel: (877)236-8820
Email: media@livestrong.org
Internet: http://www.livestrong.org

BeatSarcoma
76 Ellsworth Street
San Francisco, CA 94110
Tel: (415)651-4473
Email: info@beatsarcoma.org
Internet: http://www.beatsarcoma.org/

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org
Last Updated: 3/10/2008
Copyright 1990, 1991, 1992, 1994, 1996, 1997, 1998, 2000 National Organization for Rare Disorders, Inc.

Skin Cancer Overview

Skin cancer is the most common of all human cancers. Some form of skin cancer is diagnosed in more than 1 million people in the United States each year.
Cancer occurs when normal cells undergo a transformation during which they grow and multiply without normal controls.

• As the cells multiply, they form a mass called a tumor. Tumors of the skin are often referred to as lesions.
  
  
• Tumors are cancerous only if they are malignant. This means that they encroach on and invade neighboring tissues because of their uncontrolled growth.
  
  
• Tumors may also travel to remote organs via the bloodstream or lymphatic system.
  
  
• This process of invading and spreading to other organs is called metastasis.
  
  
• Tumors overwhelm surrounding tissues by invading their space and taking the oxygen and nutrients they need to survive and function.

Skin cancers are of three major types: basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.

• The vast majority of skin cancers are BCCs or SCCs. While malignant, these are unlikely to spread to other parts of the body. They may be locally disfiguring if not treated early.
  
  
• A small but significant number of skin cancers are malignant melanomas. Malignant melanoma is a highly aggressive cancer that tends to spread to other parts of the body. These cancers may be fatal if not treated early.

Like many cancers, skin cancers start as precancerous lesions. These precancerous lesions are changes in skin that are not cancer but could become cancer over time. Medical professionals often refer to these changes as dysplasia. Some specific dysplastic changes that occur in skin are as follows:

• Actinic keratosis is a patch of red or brown, scaly, rough skin, which can develop into squamous cell carcinoma.
  
  
• A nevus is a mole, and dysplastic nevi are abnormal moles. These can develop into melanoma over time.

Moles (nevi) are simply growths on the skin. They are very common. Very few moles become cancer.

• Most people have 10-40 moles on their body.
  
  
• Moles can be flat or raised; some begin as flat and become raised over time.
  
  
• The surface is usually smooth.
  
  
• Moles are round or oval and no larger than ¼-inch across.
  
  
• Moles are usually pink, tan, brown, or the same color as the skin. Other colors are sometimes noted.
  
  
• An individual's moles usually look pretty much alike. A mole that looks different from the others should be examined by your health-care provider.

Dysplastic nevi are not cancer, but they can become cancer.

• People with dysplastic nevi often have a lot of them, perhaps as many as 100 or more.
  
  
• People with many dysplastic nevi are more likely to develop melanoma, either within an existing nevus or on an area of normal skin.
  
  
• Dysplastic nevi are usually irregular in shape, with notched or fading borders.
  
  
• Dysplastic nevi may be flat or raised, and the surface may be smooth or rough ("pebbly").
  
  
• Dysplastic nevi are often large, ¼-inch across or even larger.
  
  
• Dysplastic nevi are typically of mixed color, including pink, red, tan, and brown.

Recent studies demonstrate that the number of skin cancer cases in the United States is growing at an alarming rate. Fortunately, increased awareness on the part of Americans and their health-care providers has resulted in earlier diagnosis and improved outcomes.

Skin Cancer Causes

Ultraviolet (UV) light exposure, most commonly from sunlight, is overwhelmingly the most frequent cause of skin cancer.
Other important causes of skin cancer include the following:

• Use of tanning booths
  
  
• Immunosuppression-impairment of the immune system, which protects the body from foreign entities, such as germs or substances that cause an allergic reaction. This may occur as a consequence of some diseases or can be due to medications prescribed to combat autoimmune diseases or prevent organ transplant rejection.
  
  
• Exposure to unusually high levels of x-rays
  
  
• Contact with certain chemicals-arsenic (miners, sheep shearers, and farmers), hydrocarbons in tar, oils, and soot (may cause squamous cell carcinoma)

The following people are at the greatest risk:

• People with fair skin, especially types that freckle, sunburn easily, or become painful in the sun
  
  
• People with light (blond or red) hair and blue or green eyes
  
  
• Those with certain genetic disorders that deplete skin pigment such as albinism, xeroderma pigmentosum
  
  
• People who have already been treated for skin cancer
  
  
• People with numerous moles, unusual moles, or large moles that were present at birth
  
  
• People with close family members who have developed skin cancer
  
  
• People who had at least one severe sunburn early in life

Basal cell carcinomas and squamous cell carcinomas are more common in older people. Melanomas are more common in younger people. For example, melanoma is the most common cancer in people 25-29 years of age.

Skin Cancer Symptoms

A basal cell carcinoma (BCC) usually looks like a raised, smooth, pearly bump on the sun-exposed skin of the head, neck, or shoulders.

• Small blood vessels may be visible within the tumor.
  
  
• A central depression with crusting and bleeding (ulceration) frequently develops.
  
  
• A BCC is often mistaken for a sore that does not heal.

A squamous cell carcinoma (SCC) is commonly a well-defined, red, scaling, thickened patch on sun-exposed skin.

• Like BCCs, SCCs may ulcerate and bleed.
  
  
• Left untreated, SCC may develop into a large mass.

The majority of malignant melanomas are brown to black pigmented lesions.

• Warning signs include change in size, shape, color, or elevation of a mole.
  
  
• The appearance of a new mole during adulthood, or new pain, itching, ulceration, or bleeding of an existing mole should all be checked by a health-care provider.

The following easy-to-remember guideline, "ABCD," is useful for identifying malignant melanoma:

• Asymmetry-One side of the lesion does not look like the other.
  
  
• Border irregularity-Margins may be notched or irregular.
  
  
• Color-Melanomas are often a mixture of black, tan, brown, blue, red, or white.
  
  
• Diameter-Cancerous lesions are usually larger than 6 mm across (about the size of a pencil eraser), but any change in size may be significant.

When to Seek Medical Care

Many people, especially those who have fair coloring or have had extensive sun exposure, should periodically check their entire body for suggestive moles and lesions.
Have your primary health-care provider or a skin specialist (dermatologist) check any moles or spots that concern you.
See your health-care provider to check your skin if you notice any changes in the size, shape, color, or texture of pigmented areas (such as darker areas of skin or moles).
If you have skin cancer, your skin specialist (dermatologist) or cancer specialist (oncologist) will talk to you about symptoms of metastatic disease that might require care in a hospital.

Exams and Tests

If you have a worrisome mole or other lesion, your primary-care provider will probably refer you to a dermatologist. The dermatologist will examine any moles in question and, in many cases, the entire skin surface.

• Any lesions that are difficult to identify, or are thought to be skin cancer, may then be checked.
  
  
• A sample of skin (biopsy) will be taken so that the suspicious area of skin can be examined under a microscope.
  
  
• A biopsy can almost always be done in the dermatologist's office.

If a biopsy shows that you have malignant melanoma, you will probably undergo further testing to determine the extent of spread of the disease, if any. This may involve blood tests, a chest x-ray, and other tests as needed.

Skin Cancer Treatment

Treatment for basal cell carcinoma and squamous cell carcinoma is straightforward. Usually, surgical removal of the lesion is adequate. Malignant melanoma, however, may require several treatment methods, including surgery, radiation therapy, and chemotherapy. Because of the complexity of treatment decisions, people with malignant melanoma may benefit from the combined expertise of the dermatologist, a cancer surgeon, and an oncologist.

Self-Care at Home

Home treatment is not appropriate for skin cancer. These conditions require the care of a dermatologist or specialist in skin cancers.
Be active in preventing and detecting skin cancer on yourself and others. Perform regular self-examinations of your skin and note any changes. Avoid unnecessary exposure to direct sunlight. Wear sunscreen daily.

Medical Treatment

Surgical removal is the mainstay of therapy for both basal cell and squamous cell carcinomas. For more information, see Surgery.
People who cannot undergo surgery may be treated by external radiation therapy. Radiation therapy is the use of a small beam of radiation targeted at the skin lesion. The radiation kills the abnormal cells and destroys the lesion. Radiation therapy can cause irritation or burning of the surrounding normal skin. It can also cause fatigue. These side effects are temporary. In addition, a topical cream has recently been approved for the treatment of certain low-risk nonmelanoma skin cancers.
In advanced cases, immune therapies, vaccines, or chemotherapy may be used. These treatments are typically offered as clinical trials. Clinical trials are studies of new therapies to see if they can be tolerated and work better than existing therapies.

Surgery

Small lesions may be removed through a variety of techniques, including simple excision (cutting it away), electrodesiccation and curettage (burning the tissue with an electric needle), and cryosurgery (freezing the area with liquid nitrogen).
Larger tumors, lesions in high-risk locations, recurrent tumors, and lesions in cosmetically sensitive areas are removed by Mohs micrographic surgery. The surgeon carefully removes tissue, layer by layer, until cancer-free tissue is reached.
Malignant melanoma is treated more aggressively than just surgical removal. To ensure the complete removal of this dangerous malignancy, 1-2 cm of normal-appearing skin surrounding the tumor is also removed. In some cases, when available, the removal is accomplished using Mohs micrographic surgery. Depending on the thickness of the melanoma, neighboring lymph nodes may also be removed and tested for cancer. The sentinel node method uses a mildly radioactive substance to identify which lymph nodes are most likely to be affected.

Next Steps

Follow-up

Most skin cancer is cured surgically in the dermatologist's office. Of skin cancers that do recur, most do so within three years. Therefore, follow up with your dermatologist (skin specialist) as recommended. Make an appointment immediately if you suspect a problem.
If you have advanced malignant melanoma, your oncologist may want to see you every few months. These visits may include total body skin examinations, regional lymph node checks, and periodic chest x-rays. Over time, the intervals between follow-up appointments will increase. Eventually these checks may be done only once a year.

Prevention

You can reduce your risk of getting skin cancer.

• Limit sun exposure. Attempt to avoid the sun's intense rays between 10 a.m. and 2 p.m.
• 
  
• Apply sunscreen frequently. Use a sunscreen with sun protection factor (SPF) of at least 15 both before and during sun exposure. Select products that block both UVA and UVB light. The label will tell you.
• 
  
• If you are likely to sunburn, wear long sleeves and a wide-brimmed hat.
• 
  
• Avoid artificial tanning booths.
• 
  
• Conduct periodic skin self-examinations.

Skin self-examination
Monthly self-examination improves your chances of finding a skin cancer early, when it has done a minimum of damage to your skin and can be treated easily. Regular self-exam helps you recognize any new or changing features.

• The best time to do a self-exam is right after a shower or bath.
• 
  
• Do the self-exam in a well-lighted room; use a full-length mirror and a handheld mirror.
• 
  
• Learn where your moles, birthmarks, and blemishes are, and what they look like.
• 
  
• Each time you do a self-exam, check these areas for changes in size, texture, and color, and for ulceration. If you notice any changes, call your primary-care provider or dermatologist.

Check all areas of your body, including "hard-to-reach" areas. Ask a loved one to help you if there are areas you can't see.

• Look in the full-length mirror at your front and your back (use the handheld mirror to do this). Raise your arms and look at your left and right sides.
• 
  
• Bend your elbows and look carefully at your palms, your forearms (front and back), and upper arms.
• 
  
• Examine the backs and fronts of your legs. Look at your buttocks (including the area between the buttocks) and your genitals (use the handheld mirror to make sure you see all skin areas).
• 
  
• Sit down and examine your feet carefully, including the soles and between the toes.
• 
  
• Look at your scalp, face, and neck. You may use a comb or blow dryer to move your hair while examining your scalp.

Outlook

Although the number of skin cancers in the United States continues to rise, more and more skin cancers are being caught earlier, when they are easier to treat. Thus, illness and death rates have decreased.
When treated properly, the cure rate for both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) approaches 95%. The remaining cancers recur at some point after treatment.

• Recurrences of these cancers are almost always local (not spread elsewhere in the body), but they often cause significant tissue destruction.
  
  
• Less than 1% of squamous cell carcinomas will eventually spread elsewhere in the body and turn into dangerous cancer.

In most cases, the outcome of malignant melanoma depends on the thickness of the tumor at the time of treatment.

• Thin lesions are almost always cured by simple surgery alone.
  
  
• Thicker tumors, which usually have been present for some time but have gone undetected, may spread to other organs. Surgery removes the tumor and any local spread, but it cannot remove distant metastasis. Other therapies, such as radiation therapy or chemotherapy, are used to treat the metastatic tumors.
  
  
• Malignant melanoma causes more than 75% of deaths from skin cancer.
  
  
• Of the approximately 100,000 malignant melanomas diagnosed in the United States in 2007, the vast majority were cured. Still, thousands of people die of melanoma each year.