Cancer, breast,
susceptibility genes: Inherited factors that predispose to breast
cancer. Put otherwise, these genes make one more susceptible to the
disease and so increase the risk of developing breast cancer. Two of
these genes, BRCA1 and BRCA2, have been identified (and prominently
publicized). Several other genes (those for the Li-Fraumeni syndrome,
Cowden disease, Muir-Torre syndrome, and ataxia-telangiectasia) are also
known to predispose to breast cancer. However, since all of these known
breast cancer susceptibility genes together do not account for more
than a minor fraction (1/5th at most) of breast cancer that clusters in
families, it is clear that more breast cancer genes remain to be
discovered.
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